Which statement about ASBT is true?

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Study for the ACVIM Small Animal Internal Medicine Exam to enhance your veterinary knowledge. Prepare with flashcards and multiple-choice questions, featuring hints and explanations. Ensure success in your exam journey!

Multiple Choice

Which statement about ASBT is true?

Explanation:
ASBT is the apical sodium-dependent bile acid transporter that sits on ileal enterocytes and drives the reabsorption of bile acids from the intestinal lumen as part of enterohepatic circulation. This process is powered by the sodium gradient, meaning ASBT uses Na+ to bring bile acids into the cell. The main site of this reclamation is the ileum, which is why the statement about reabsorbing bile acids in the ileum is true. It’s not purely exclusive to the ileum (there is some expression elsewhere, such as in the kidney), and reabsorption in the colon is minimal compared to the ileum. It certainly does not function without sodium.

ASBT is the apical sodium-dependent bile acid transporter that sits on ileal enterocytes and drives the reabsorption of bile acids from the intestinal lumen as part of enterohepatic circulation. This process is powered by the sodium gradient, meaning ASBT uses Na+ to bring bile acids into the cell. The main site of this reclamation is the ileum, which is why the statement about reabsorbing bile acids in the ileum is true. It’s not purely exclusive to the ileum (there is some expression elsewhere, such as in the kidney), and reabsorption in the colon is minimal compared to the ileum. It certainly does not function without sodium.

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