Which secondary bile acids are produced from cholic acid and chenodeoxycholic acid, respectively?

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Study for the ACVIM Small Animal Internal Medicine Exam to enhance your veterinary knowledge. Prepare with flashcards and multiple-choice questions, featuring hints and explanations. Ensure success in your exam journey!

Multiple Choice

Which secondary bile acids are produced from cholic acid and chenodeoxycholic acid, respectively?

Explanation:
Secondary bile acids are formed when gut bacteria modify primary bile acids produced in the liver. The liver makes two primary bile acids: cholic acid and chenodeoxycholic acid. Bacterial 7α-dehydroxylation converts cholic acid into deoxycholic acid, and converts chenodeoxycholic acid into lithocholic acid. Therefore, the secondary bile acids produced from cholic acid and chenodeoxycholic acid, respectively, are deoxycholic acid and lithocholic acid. (Ursodeoxycholic acid can be formed from chenodeoxycholic acid in some pathways, but the classic products from CA and CDCA are DCA and LCA.)

Secondary bile acids are formed when gut bacteria modify primary bile acids produced in the liver. The liver makes two primary bile acids: cholic acid and chenodeoxycholic acid. Bacterial 7α-dehydroxylation converts cholic acid into deoxycholic acid, and converts chenodeoxycholic acid into lithocholic acid. Therefore, the secondary bile acids produced from cholic acid and chenodeoxycholic acid, respectively, are deoxycholic acid and lithocholic acid. (Ursodeoxycholic acid can be formed from chenodeoxycholic acid in some pathways, but the classic products from CA and CDCA are DCA and LCA.)

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