Which biomarker is used with ALP staining to detect osteosarcoma (OSA)?

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Study for the ACVIM Small Animal Internal Medicine Exam to enhance your veterinary knowledge. Prepare with flashcards and multiple-choice questions, featuring hints and explanations. Ensure success in your exam journey!

Multiple Choice

Which biomarker is used with ALP staining to detect osteosarcoma (OSA)?

Explanation:
Alkaline phosphatase is a marker of osteoblastic activity and bone formation. Osteosarcoma arises from osteoblast-like cells that often produce osteoid and show high ALP expression, so staining for alkaline phosphatase highlights these osteogenic tumor cells and helps identify the lesion. Other enzymes like LDH, CK, and GGT are not specific to bone formation or osteoblastic differentiation, so they don’t serve this purpose in detecting osteosarcoma.

Alkaline phosphatase is a marker of osteoblastic activity and bone formation. Osteosarcoma arises from osteoblast-like cells that often produce osteoid and show high ALP expression, so staining for alkaline phosphatase highlights these osteogenic tumor cells and helps identify the lesion. Other enzymes like LDH, CK, and GGT are not specific to bone formation or osteoblastic differentiation, so they don’t serve this purpose in detecting osteosarcoma.

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