In the feline GI study, CD11b+ cells are proposed to represent which cell type?

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Study for the ACVIM Small Animal Internal Medicine Exam to enhance your veterinary knowledge. Prepare with flashcards and multiple-choice questions, featuring hints and explanations. Ensure success in your exam journey!

Multiple Choice

In the feline GI study, CD11b+ cells are proposed to represent which cell type?

Explanation:
CD11b is a marker of cells of the myeloid lineage, part of the Mac-1 integrin complex (CD11b/CD18) that’s expressed on monocytes/macrophages, neutrophils, and many dendritic cells. In feline GI tissue, labeling with CD11b+ identifies these myeloid-derived innate immune cells rather than lymphocytes or epithelial cells. T lymphocytes carry markers like CD3 and CD4/CD8, while B lymphocytes carry CD79a/CD21, and epithelial cells express epithelial markers such as cytokeratins, not CD11b. So, CD11b+ cells in this context point to myeloid cells, including macrophages and neutrophils, involved in mucosal immunity and inflammation.

CD11b is a marker of cells of the myeloid lineage, part of the Mac-1 integrin complex (CD11b/CD18) that’s expressed on monocytes/macrophages, neutrophils, and many dendritic cells. In feline GI tissue, labeling with CD11b+ identifies these myeloid-derived innate immune cells rather than lymphocytes or epithelial cells. T lymphocytes carry markers like CD3 and CD4/CD8, while B lymphocytes carry CD79a/CD21, and epithelial cells express epithelial markers such as cytokeratins, not CD11b. So, CD11b+ cells in this context point to myeloid cells, including macrophages and neutrophils, involved in mucosal immunity and inflammation.

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