In humans with IBD, ASBT expression is decreased due to what?

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Study for the ACVIM Small Animal Internal Medicine Exam to enhance your veterinary knowledge. Prepare with flashcards and multiple-choice questions, featuring hints and explanations. Ensure success in your exam journey!

Multiple Choice

In humans with IBD, ASBT expression is decreased due to what?

Explanation:
Inflammation-driven regulation of intestinal transporters is at play. In IBD, pro-inflammatory cytokines released in the gut signal enterocytes to downregulate the ileal apical bile acid transporter ASBT (encoded by SLC10A2), lowering its expression on the luminal surface. This cytokine-mediated repression reduces bile acid reabsorption from the ileum. It’s a direct effect of inflammatory signaling rather than a genetic mutation in ASBT, hepatic dysfunction, or dysbiosis, though those factors can influence bile acid biology in other ways.

Inflammation-driven regulation of intestinal transporters is at play. In IBD, pro-inflammatory cytokines released in the gut signal enterocytes to downregulate the ileal apical bile acid transporter ASBT (encoded by SLC10A2), lowering its expression on the luminal surface. This cytokine-mediated repression reduces bile acid reabsorption from the ileum. It’s a direct effect of inflammatory signaling rather than a genetic mutation in ASBT, hepatic dysfunction, or dysbiosis, though those factors can influence bile acid biology in other ways.

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