In control dogs, ASBT protein had the highest immunolabeling in which intestinal segment?

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Study for the ACVIM Small Animal Internal Medicine Exam to enhance your veterinary knowledge. Prepare with flashcards and multiple-choice questions, featuring hints and explanations. Ensure success in your exam journey!

Multiple Choice

In control dogs, ASBT protein had the highest immunolabeling in which intestinal segment?

Explanation:
ASBT is the apical sodium-dependent bile acid transporter, the main mechanism for actively reabsorbing bile acids from the intestinal lumen. In dogs, its expression is greatest in the ileum, especially the distal/terminal portion, where enterocytes densely express ASBT on their luminal surface to reclaim bile acids into the portal circulation. Because of this high local abundance, immunolabeling for ASBT is strongest in the ileum of control dogs. The duodenum has some expression but much less, and the colon/cecum show minimal labeling since most bile acids are reabsorbed earlier in the small intestine.

ASBT is the apical sodium-dependent bile acid transporter, the main mechanism for actively reabsorbing bile acids from the intestinal lumen. In dogs, its expression is greatest in the ileum, especially the distal/terminal portion, where enterocytes densely express ASBT on their luminal surface to reclaim bile acids into the portal circulation. Because of this high local abundance, immunolabeling for ASBT is strongest in the ileum of control dogs. The duodenum has some expression but much less, and the colon/cecum show minimal labeling since most bile acids are reabsorbed earlier in the small intestine.

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