How is lesion morphology used to assess aggressiveness of a lesion?

• A. Aggressive disease: ill-defined or poorly delineated margins; benign lesions: well-defined margins
• B. Aggressive disease: well-defined margins
• C. All lesions with any bone loss are aggressive
• D. Morphology is not related to aggressiveness

Answer: (A)

Imaging margins reflect how a lesion grows. Aggressive lesions tend to invade surrounding bone and soft tissue, producing ill-defined, poorly delineated borders, while benign lesions are usually well-defined and smoothly marginated as they expand rather than invade. Therefore, describing aggressive disease as having ill-defined margins and benign lesions as having well-defined margins best captures how morphology relates to aggressiveness. The other statements are less accurate because well-defined margins can be seen with non-aggressive lesions, bone loss isn’t a definitive indicator of aggressiveness, and morphology does relate to aggressiveness.